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Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI
Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological fea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413300/ https://www.ncbi.nlm.nih.gov/pubmed/28491496 http://dx.doi.org/10.1016/j.nicl.2017.04.017 |
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author | Adler, Sophie Lorio, Sara Jacques, Thomas S. Benova, Barbora Gunny, Roxana Cross, J. Helen Baldeweg, Torsten Carmichael, David W. |
author_facet | Adler, Sophie Lorio, Sara Jacques, Thomas S. Benova, Barbora Gunny, Roxana Cross, J. Helen Baldeweg, Torsten Carmichael, David W. |
author_sort | Adler, Sophie |
collection | PubMed |
description | Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological features. Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology. This review will cover histological, genetic and radiological features of FCD following the ILAE classification and will explain how quantitative voxel- and surface-based techniques can characterise these features. We will provide an overview of the quantitative MRI measures available, their link with biophysical properties and finally the potential application of quantitative MRI to the problem of FCD subtyping. Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual. |
format | Online Article Text |
id | pubmed-5413300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54133002017-05-10 Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI Adler, Sophie Lorio, Sara Jacques, Thomas S. Benova, Barbora Gunny, Roxana Cross, J. Helen Baldeweg, Torsten Carmichael, David W. Neuroimage Clin Review Article Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological features. Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology. This review will cover histological, genetic and radiological features of FCD following the ILAE classification and will explain how quantitative voxel- and surface-based techniques can characterise these features. We will provide an overview of the quantitative MRI measures available, their link with biophysical properties and finally the potential application of quantitative MRI to the problem of FCD subtyping. Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual. Elsevier 2017-04-20 /pmc/articles/PMC5413300/ /pubmed/28491496 http://dx.doi.org/10.1016/j.nicl.2017.04.017 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Adler, Sophie Lorio, Sara Jacques, Thomas S. Benova, Barbora Gunny, Roxana Cross, J. Helen Baldeweg, Torsten Carmichael, David W. Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title | Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title_full | Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title_fullStr | Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title_full_unstemmed | Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title_short | Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI |
title_sort | towards in vivo focal cortical dysplasia phenotyping using quantitative mri |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413300/ https://www.ncbi.nlm.nih.gov/pubmed/28491496 http://dx.doi.org/10.1016/j.nicl.2017.04.017 |
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