Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT...

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Detalles Bibliográficos
Autores principales: Moffitt, Andrea B., Ondrejka, Sarah L., McKinney, Matthew, Rempel, Rachel E., Goodlad, John R., Teh, Chun Huat, Leppa, Sirpa, Mannisto, Susanna, Kovanen, Panu E., Tse, Eric, Au-Yeung, Rex K.H., Kwong, Yok-Lam, Srivastava, Gopesh, Iqbal, Javeed, Yu, Jiayu, Naresh, Kikkeri, Villa, Diego, Gascoyne, Randy D., Said, Jonathan, Czader, Magdalena B., Chadburn, Amy, Richards, Kristy L., Rajagopalan, Deepthi, Davis, Nicholas S., Smith, Eileen C., Palus, Brooke C., Tzeng, Tiffany J., Healy, Jane A., Lugar, Patricia L., Datta, Jyotishka, Love, Cassandra, Levy, Shawn, Dunson, David B., Zhuang, Yuan, Hsi, Eric D., Dave, Sandeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413324/
https://www.ncbi.nlm.nih.gov/pubmed/28424246
http://dx.doi.org/10.1084/jem.20160894

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