Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation

Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor. Using mouse models, we show that hepatocyte-specific deletion of c-Fos protects against diethylnitrosamine (DEN)-induced HCCs, wh...

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Detalles Bibliográficos
Autores principales: Bakiri, Latifa, Hamacher, Rainer, Graña, Osvaldo, Guío-Carrión, Ana, Campos-Olivas, Ramón, Martinez, Lola, Dienes, Hans P., Thomsen, Martin K., Hasenfuss, Sebastian C., Wagner, Erwin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413325/
https://www.ncbi.nlm.nih.gov/pubmed/28356389
http://dx.doi.org/10.1084/jem.20160935

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