Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-...

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Detalles Bibliográficos
Autores principales: Kräutler, Nike J., Suan, Dan, Butt, Danyal, Bourne, Katherine, Hermes, Jana R., Chan, Tyani D., Sundling, Christopher, Kaplan, Warren, Schofield, Peter, Jackson, Jennifer, Basten, Antony, Christ, Daniel, Brink, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413338/
https://www.ncbi.nlm.nih.gov/pubmed/28363897
http://dx.doi.org/10.1084/jem.20161533

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