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MINK1: The missing link between ROS and its inhibition of Th17 cells
In this issue of JEM, Fu et al. (https://doi.org/10.1084/jem.20161120) identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-β activation of Smad2, therefore limiting Th17 cell differentiation.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413342/ https://www.ncbi.nlm.nih.gov/pubmed/28420734 http://dx.doi.org/10.1084/jem.20170571 |
| _version_ | 1783233172610220032 |
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| author | Martinez, Gustavo J. |
| author_facet | Martinez, Gustavo J. |
| author_sort | Martinez, Gustavo J. |
| collection | PubMed |
| description | In this issue of JEM, Fu et al. (https://doi.org/10.1084/jem.20161120) identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-β activation of Smad2, therefore limiting Th17 cell differentiation. |
| format | Online Article Text |
| id | pubmed-5413342 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54133422017-11-01 MINK1: The missing link between ROS and its inhibition of Th17 cells Martinez, Gustavo J. J Exp Med News In this issue of JEM, Fu et al. (https://doi.org/10.1084/jem.20161120) identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-β activation of Smad2, therefore limiting Th17 cell differentiation. The Rockefeller University Press 2017-05-01 /pmc/articles/PMC5413342/ /pubmed/28420734 http://dx.doi.org/10.1084/jem.20170571 Text en © 2017 Martinez http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | News Martinez, Gustavo J. MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title | MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title_full | MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title_fullStr | MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title_full_unstemmed | MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title_short | MINK1: The missing link between ROS and its inhibition of Th17 cells |
| title_sort | mink1: the missing link between ros and its inhibition of th17 cells |
| topic | News |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413342/ https://www.ncbi.nlm.nih.gov/pubmed/28420734 http://dx.doi.org/10.1084/jem.20170571 |
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