Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biom...

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Detalles Bibliográficos
Autores principales: Cui, Jixin, Zhu, Qinyu, Zhang, Hui, Cianfrocco, Michael A, Leschziner, Andres E, Dixon, Jack E, Xiao, Junyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413348/
https://www.ncbi.nlm.nih.gov/pubmed/28432788
http://dx.doi.org/10.7554/eLife.23990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413348/
https://www.ncbi.nlm.nih.gov/pubmed/28432788
http://dx.doi.org/10.7554/eLife.23990

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