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Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeF(x), and an ESCRT-III substrate pepti...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413351/ https://www.ncbi.nlm.nih.gov/pubmed/28379137 http://dx.doi.org/10.7554/eLife.24487 |