Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss. Here, we report that reduced SMN function impacts the action of a pertinent microRNA and its mRNA target in MNs. Loss o...

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Detalles Bibliográficos
Autores principales: O'Hern, Patrick J, do Carmo G. Gonçalves, Inês, Brecht, Johanna, López Soto, Eduardo Javier, Simon, Jonah, Chapkis, Natalie, Lipscombe, Diane, Kye, Min Jeong, Hart, Anne C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413352/
https://www.ncbi.nlm.nih.gov/pubmed/28463115
http://dx.doi.org/10.7554/eLife.20752

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