The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms

The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis. Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel and promising class of drugs for T2DM, which may also have...

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Autores principales: Zhao, Chenhe, Liang, Jing, Yang, Yinqiu, Yu, Mingxiang, Qu, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413504/
https://www.ncbi.nlm.nih.gov/pubmed/28515711
http://dx.doi.org/10.3389/fendo.2017.00098
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author Zhao, Chenhe
Liang, Jing
Yang, Yinqiu
Yu, Mingxiang
Qu, Xinhua
author_facet Zhao, Chenhe
Liang, Jing
Yang, Yinqiu
Yu, Mingxiang
Qu, Xinhua
author_sort Zhao, Chenhe
collection PubMed
description The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis. Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel and promising class of drugs for T2DM, which may also have clinical applications in bone tissue disorders. This review examines the impact of GLP-1 on bone metabolism, including enhancement of bone mineral density and improvement of bone quality. However, the precise effect of GLP-1 on fracture risk has not been unambiguously defined. This review also summarizes our current understanding of the mechanisms by which GLP-1 affects bone metabolism. GLP-1 may act on bone by promoting bone formation, inhibiting bone resorption, and affecting the coordination of the two processes. We describe molecular pathways and proteins, such as Wnt and calcitonin, that are associated with GLP-1 and bone tissue. The specific processes and related molecular mechanisms of the effects of GLP-1 on bone metabolism need to be further explored and clarified.
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spelling pubmed-54135042017-05-17 The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms Zhao, Chenhe Liang, Jing Yang, Yinqiu Yu, Mingxiang Qu, Xinhua Front Endocrinol (Lausanne) Endocrinology The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis. Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel and promising class of drugs for T2DM, which may also have clinical applications in bone tissue disorders. This review examines the impact of GLP-1 on bone metabolism, including enhancement of bone mineral density and improvement of bone quality. However, the precise effect of GLP-1 on fracture risk has not been unambiguously defined. This review also summarizes our current understanding of the mechanisms by which GLP-1 affects bone metabolism. GLP-1 may act on bone by promoting bone formation, inhibiting bone resorption, and affecting the coordination of the two processes. We describe molecular pathways and proteins, such as Wnt and calcitonin, that are associated with GLP-1 and bone tissue. The specific processes and related molecular mechanisms of the effects of GLP-1 on bone metabolism need to be further explored and clarified. Frontiers Media S.A. 2017-05-03 /pmc/articles/PMC5413504/ /pubmed/28515711 http://dx.doi.org/10.3389/fendo.2017.00098 Text en Copyright © 2017 Zhao, Liang, Yang, Yu and Qu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhao, Chenhe
Liang, Jing
Yang, Yinqiu
Yu, Mingxiang
Qu, Xinhua
The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title_full The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title_fullStr The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title_full_unstemmed The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title_short The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
title_sort impact of glucagon-like peptide-1 on bone metabolism and its possible mechanisms
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413504/
https://www.ncbi.nlm.nih.gov/pubmed/28515711
http://dx.doi.org/10.3389/fendo.2017.00098
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