Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD. By elucidating the function of the caspase-8 homolog, caspase-10, we discover that caspase-10 negatively regulate...

Descripción completa

Detalles Bibliográficos
Autores principales: Horn, Sebastian, Hughes, Michelle A., Schilling, Ramon, Sticht, Carsten, Tenev, Tencho, Ploesser, Michaela, Meier, Pascal, Sprick, Martin R., MacFarlane, Marion, Leverkus, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413585/
https://www.ncbi.nlm.nih.gov/pubmed/28445729
http://dx.doi.org/10.1016/j.celrep.2017.04.010

Ejemplares similares

Ejemplares similares