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CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells (iPSCs)...

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Detalles Bibliográficos
Autores principales:	Wang, Lixia, Yi, Fei, Fu, Lina, Yang, Jiping, Wang, Si, Wang, Zhaoxia, Suzuki, Keiichiro, Sun, Liang, Xu, Xiuling, Yu, Yang, Qiao, Jie, Belmonte, Juan Carlos Izpisua, Yang, Ze, Yuan, Yun, Qu, Jing, Liu, Guang-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413600/ https://www.ncbi.nlm.nih.gov/pubmed/28401346 http://dx.doi.org/10.1007/s13238-017-0397-3

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