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Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability

Antibody disulfide bond reduction during monoclonal antibody (mAb) production is a phenomenon that has been attributed to the reducing enzymes from CHO cells acting on the mAb during the harvest process. However, the impact of antibody reduction on the downstream purification process has not been st...

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Detalles Bibliográficos
Autores principales:	Chung, Wai Keen, Russell, Brian, Yang, Yanhong, Handlogten, Michael, Hudak, Suzanne, Cao, Mingyan, Wang, Jihong, Robbins, David, Ahuja, Sanjeev, Zhu, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413809/ https://www.ncbi.nlm.nih.gov/pubmed/28186329 http://dx.doi.org/10.1002/bit.26265

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