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Emerging applications of exosomes in cancer therapeutics and diagnostics
Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluid...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413841/ https://www.ncbi.nlm.nih.gov/pubmed/28529978 http://dx.doi.org/10.1002/btm2.10059 |
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author | Inamdar, Sahil Nitiyanandan, Rajeshwar Rege, Kaushal |
author_facet | Inamdar, Sahil Nitiyanandan, Rajeshwar Rege, Kaushal |
author_sort | Inamdar, Sahil |
collection | PubMed |
description | Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state‐of‐the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics. |
format | Online Article Text |
id | pubmed-5413841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54138412017-05-19 Emerging applications of exosomes in cancer therapeutics and diagnostics Inamdar, Sahil Nitiyanandan, Rajeshwar Rege, Kaushal Bioeng Transl Med Reviews Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state‐of‐the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics. John Wiley and Sons Inc. 2017-04-03 /pmc/articles/PMC5413841/ /pubmed/28529978 http://dx.doi.org/10.1002/btm2.10059 Text en © 2017 The Authors. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Inamdar, Sahil Nitiyanandan, Rajeshwar Rege, Kaushal Emerging applications of exosomes in cancer therapeutics and diagnostics |
title | Emerging applications of exosomes in cancer therapeutics and diagnostics |
title_full | Emerging applications of exosomes in cancer therapeutics and diagnostics |
title_fullStr | Emerging applications of exosomes in cancer therapeutics and diagnostics |
title_full_unstemmed | Emerging applications of exosomes in cancer therapeutics and diagnostics |
title_short | Emerging applications of exosomes in cancer therapeutics and diagnostics |
title_sort | emerging applications of exosomes in cancer therapeutics and diagnostics |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413841/ https://www.ncbi.nlm.nih.gov/pubmed/28529978 http://dx.doi.org/10.1002/btm2.10059 |
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