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PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3 promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify a new role for the Pif1 helicase: promotion of replication and suppression of DNA damage at tDNAs. Pif1 binds multiple tDNAs,...

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Detalles Bibliográficos
Autores principales:	Tran, Phong Lan Thao, Pohl, Thomas J., Chen, Chi-Fu, Chan, Angela, Pott, Sebastian, Zakian, Virginia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413955/ https://www.ncbi.nlm.nih.gov/pubmed/28429714 http://dx.doi.org/10.1038/ncomms15025

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