A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous (‘weak' or ‘noisy') density is experimentally common, since molecular states are generally only fractionally present in the crystal. Exi...

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Detalles Bibliográficos
Autores principales: Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413968/
https://www.ncbi.nlm.nih.gov/pubmed/28436492
http://dx.doi.org/10.1038/ncomms15123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413968/
https://www.ncbi.nlm.nih.gov/pubmed/28436492
http://dx.doi.org/10.1038/ncomms15123

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