Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells

Angelman syndrome (AS) is a neurogenetic disorder caused by deletion of the maternally inherited UBE3A allele and is characterized by developmental delay, intellectual disability, ataxia, seizures and a happy affect. Here, we explored the underlying pathophysiology using induced pluripotent stem cel...

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Detalles Bibliográficos
Autores principales: Fink, James J., Robinson, Tiwanna M., Germain, Noelle D., Sirois, Carissa L., Bolduc, Kaitlyn A., Ward, Amanda J., Rigo, Frank, Chamberlain, Stormy J., Levine, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413969/
https://www.ncbi.nlm.nih.gov/pubmed/28436452
http://dx.doi.org/10.1038/ncomms15038

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