DNA single-strand break-induced DNA damage response causes heart failure

The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single-strand b...

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Detalles Bibliográficos
Autores principales: Higo, Tomoaki, Naito, Atsuhiko T., Sumida, Tomokazu, Shibamoto, Masato, Okada, Katsuki, Nomura, Seitaro, Nakagawa, Akito, Yamaguchi, Toshihiro, Sakai, Taku, Hashimoto, Akihito, Kuramoto, Yuki, Ito, Masamichi, Hikoso, Shungo, Akazawa, Hiroshi, Lee, Jong-Kook, Shiojima, Ichiro, McKinnon, Peter J., Sakata, Yasushi, Komuro, Issei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413978/
https://www.ncbi.nlm.nih.gov/pubmed/28436431
http://dx.doi.org/10.1038/ncomms15104

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