Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells

Neurons reprogramme encephalitogenic T cells (T(enc)) to regulatory T cells (T(regs)), either FoxP3(+)T(regs) or FoxA1(+)T(regs). We reported previously that neuronal ability to generate FoxA1(+)T(regs) was central to preventing neuroinflammation in experimental autoimmune encephalomyelitis (EAE). M...

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Detalles Bibliográficos
Autores principales: Liu, Yawei, Marin, Andrea, Ejlerskov, Patrick, Rasmussen, Louise Munk, Prinz, Marco, Issazadeh-Navikas, Shohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413980/
https://www.ncbi.nlm.nih.gov/pubmed/28436428
http://dx.doi.org/10.1038/ncomms14709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413980/
https://www.ncbi.nlm.nih.gov/pubmed/28436428
http://dx.doi.org/10.1038/ncomms14709

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