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Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1(+)T(reg) cells
Neurons reprogramme encephalitogenic T cells (T(enc)) to regulatory T cells (T(regs)), either FoxP3(+)T(regs) or FoxA1(+)T(regs). We reported previously that neuronal ability to generate FoxA1(+)T(regs) was central to preventing neuroinflammation in experimental autoimmune encephalomyelitis (EAE). M...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413980/ https://www.ncbi.nlm.nih.gov/pubmed/28436428 http://dx.doi.org/10.1038/ncomms14709 |