Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib

We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system my...

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Autores principales: Messina, Julia A., Maziarz, Eileen K., Spec, Andrej, Kontoyiannis, Dimitrios P., Perfect, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413986/
https://www.ncbi.nlm.nih.gov/pubmed/28480254
http://dx.doi.org/10.1093/ofid/ofw261
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author Messina, Julia A.
Maziarz, Eileen K.
Spec, Andrej
Kontoyiannis, Dimitrios P.
Perfect, John R.
author_facet Messina, Julia A.
Maziarz, Eileen K.
Spec, Andrej
Kontoyiannis, Dimitrios P.
Perfect, John R.
author_sort Messina, Julia A.
collection PubMed
description We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.
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spelling pubmed-54139862017-05-05 Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib Messina, Julia A. Maziarz, Eileen K. Spec, Andrej Kontoyiannis, Dimitrios P. Perfect, John R. Open Forum Infect Dis Brief Report We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib. Oxford University Press 2017-02-09 /pmc/articles/PMC5413986/ /pubmed/28480254 http://dx.doi.org/10.1093/ofid/ofw261 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Messina, Julia A.
Maziarz, Eileen K.
Spec, Andrej
Kontoyiannis, Dimitrios P.
Perfect, John R.
Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title_full Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title_fullStr Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title_full_unstemmed Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title_short Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib
title_sort disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413986/
https://www.ncbi.nlm.nih.gov/pubmed/28480254
http://dx.doi.org/10.1093/ofid/ofw261
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