A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebrates to generate tissue responses that actively block repli...

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Detalles Bibliográficos
Autores principales: Pryke, Kara M., Abraham, Jinu, Sali, Tina M., Gall, Bryan J., Archer, Iris, Liu, Andrew, Bambina, Shelly, Baird, Jason, Gough, Michael, Chakhtoura, Marita, Haddad, Elias K., Kirby, Ilsa T., Nilsen, Aaron, Streblow, Daniel N., Hirsch, Alec J., Smith, Jessica L., DeFilippis, Victor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414005/
https://www.ncbi.nlm.nih.gov/pubmed/28465426
http://dx.doi.org/10.1128/mBio.00452-17

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