FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Feng, Jin, Ke, Shao, Li, Fan, Yao, Tu, Yifei, Li, Yihao, Yang, Bin, van Dam, Hans, ten Dijke, Peter, Weng, Honglei, Dooley, Steven, Wang, Shuai, Jia, Junling, Jin, Jin, Zhou, Fangfang, Zhang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414047/
https://www.ncbi.nlm.nih.gov/pubmed/28443643
http://dx.doi.org/10.1038/ncomms15021

Ejemplares similares

Ejemplares similares