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Programming mRNA decay to modulate synthetic circuit resource allocation

Synthetic circuits embedded in host cells compete with cellular processes for limited intracellular resources. Here we show how funnelling of cellular resources, after global transcriptome degradation by the sequence-dependent endoribonuclease MazF, to a synthetic circuit can increase production. Ta...

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Detalles Bibliográficos
Autores principales:	Venturelli, Ophelia S., Tei, Mika, Bauer, Stefan, Chan, Leanne Jade G., Petzold, Christopher J., Arkin, Adam P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414051/ https://www.ncbi.nlm.nih.gov/pubmed/28443619 http://dx.doi.org/10.1038/ncomms15128

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