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APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease

Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals, with unique causal mutations suggesting the role of modifying genetic and environmental interactions. We analyzed ~50 000 common and rare functional genomic variants from 71 individuals of the ‘Paisa' pedigre...

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Detalles Bibliográficos
Autores principales:	Vélez, J I, Lopera, F, Sepulveda-Falla, D, Patel, H R, Johar, A S, Chuah, A, Tobón, C, Rivera, D, Villegas, A, Cai, Y, Peng, K, Arkell, R, Castellanos, F X, Andrews, S J, Silva Lara, M F, Creagh, P K, Easteal, S, de Leon, J, Wong, M L, Licinio, J, Mastronardi, C A, Arcos-Burgos, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414071/ https://www.ncbi.nlm.nih.gov/pubmed/26619808 http://dx.doi.org/10.1038/mp.2015.177

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