Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus

Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitoc...

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Detalles Bibliográficos
Autores principales: Kasahara, T, Takata, A, Kato, T M, Kubota-Sakashita, M, Sawada, T, Kakita, A, Mizukami, H, Kaneda, D, Ozawa, K, Kato, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414076/
https://www.ncbi.nlm.nih.gov/pubmed/26481320
http://dx.doi.org/10.1038/mp.2015.156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414076/
https://www.ncbi.nlm.nih.gov/pubmed/26481320
http://dx.doi.org/10.1038/mp.2015.156

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