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Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero
Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mothe...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414097/ https://www.ncbi.nlm.nih.gov/pubmed/28480292 http://dx.doi.org/10.1093/ofid/ofx022 |
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| author | Prahl, Mary Jagannathan, Prasanna McIntyre, Tara I. Auma, Ann Wamala, Samuel Nalubega, Mayimuna Musinguzi, Kenneth Naluwu, Kate Sikyoma, Esther Budker, Rachel Odorizzi, Pamela Kakuru, Abel Havlir, Diane V. Kamya, Moses R. Dorsey, Grant Feeney, Margaret E. |
| author_facet | Prahl, Mary Jagannathan, Prasanna McIntyre, Tara I. Auma, Ann Wamala, Samuel Nalubega, Mayimuna Musinguzi, Kenneth Naluwu, Kate Sikyoma, Esther Budker, Rachel Odorizzi, Pamela Kakuru, Abel Havlir, Diane V. Kamya, Moses R. Dorsey, Grant Feeney, Margaret E. |
| author_sort | Prahl, Mary |
| collection | PubMed |
| description | Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([T(reg)] CD4(+)CD25(+)FoxP3(+)CD127(lo/−)) differed by infant sex, with significantly lower frequencies of T(regs) in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants. |
| format | Online Article Text |
| id | pubmed-5414097 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54140972017-05-05 Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero Prahl, Mary Jagannathan, Prasanna McIntyre, Tara I. Auma, Ann Wamala, Samuel Nalubega, Mayimuna Musinguzi, Kenneth Naluwu, Kate Sikyoma, Esther Budker, Rachel Odorizzi, Pamela Kakuru, Abel Havlir, Diane V. Kamya, Moses R. Dorsey, Grant Feeney, Margaret E. Open Forum Infect Dis Brief Report Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([T(reg)] CD4(+)CD25(+)FoxP3(+)CD127(lo/−)) differed by infant sex, with significantly lower frequencies of T(regs) in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants. Oxford University Press 2017-02-11 /pmc/articles/PMC5414097/ /pubmed/28480292 http://dx.doi.org/10.1093/ofid/ofx022 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Prahl, Mary Jagannathan, Prasanna McIntyre, Tara I. Auma, Ann Wamala, Samuel Nalubega, Mayimuna Musinguzi, Kenneth Naluwu, Kate Sikyoma, Esther Budker, Rachel Odorizzi, Pamela Kakuru, Abel Havlir, Diane V. Kamya, Moses R. Dorsey, Grant Feeney, Margaret E. Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title | Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title_full | Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title_fullStr | Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title_full_unstemmed | Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title_short | Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero |
| title_sort | sex disparity in cord blood foxp3(+) cd4 t regulatory cells in infants exposed to malaria in utero |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414097/ https://www.ncbi.nlm.nih.gov/pubmed/28480292 http://dx.doi.org/10.1093/ofid/ofx022 |
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