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Spatial working memory alters the efficacy of input to visual cortex

Prefrontal cortex modulates sensory signals in extrastriate visual cortex, in part via its direct projections from the frontal eye field (FEF), an area involved in selective attention. We find that working memory-related activity is a dominant signal within FEF input to visual cortex. Although this...

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Autores principales: Merrikhi, Yaser, Clark, Kelsey, Albarran, Eddy, Parsa, Mohammadbagher, Zirnsak, Marc, Moore, Tirin, Noudoost, Behrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414175/
https://www.ncbi.nlm.nih.gov/pubmed/28447609
http://dx.doi.org/10.1038/ncomms15041
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author Merrikhi, Yaser
Clark, Kelsey
Albarran, Eddy
Parsa, Mohammadbagher
Zirnsak, Marc
Moore, Tirin
Noudoost, Behrad
author_facet Merrikhi, Yaser
Clark, Kelsey
Albarran, Eddy
Parsa, Mohammadbagher
Zirnsak, Marc
Moore, Tirin
Noudoost, Behrad
author_sort Merrikhi, Yaser
collection PubMed
description Prefrontal cortex modulates sensory signals in extrastriate visual cortex, in part via its direct projections from the frontal eye field (FEF), an area involved in selective attention. We find that working memory-related activity is a dominant signal within FEF input to visual cortex. Although this signal alone does not evoke spiking responses in areas V4 and MT during memory, the gain of visual responses in these areas increases, and neuronal receptive fields expand and shift towards the remembered location, improving the stimulus representation by neuronal populations. These results provide a basis for enhancing the representation of working memory targets and implicate persistent FEF activity as a basis for the interdependence of working memory and selective attention.
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spelling pubmed-54141752017-05-17 Spatial working memory alters the efficacy of input to visual cortex Merrikhi, Yaser Clark, Kelsey Albarran, Eddy Parsa, Mohammadbagher Zirnsak, Marc Moore, Tirin Noudoost, Behrad Nat Commun Article Prefrontal cortex modulates sensory signals in extrastriate visual cortex, in part via its direct projections from the frontal eye field (FEF), an area involved in selective attention. We find that working memory-related activity is a dominant signal within FEF input to visual cortex. Although this signal alone does not evoke spiking responses in areas V4 and MT during memory, the gain of visual responses in these areas increases, and neuronal receptive fields expand and shift towards the remembered location, improving the stimulus representation by neuronal populations. These results provide a basis for enhancing the representation of working memory targets and implicate persistent FEF activity as a basis for the interdependence of working memory and selective attention. Nature Publishing Group 2017-04-27 /pmc/articles/PMC5414175/ /pubmed/28447609 http://dx.doi.org/10.1038/ncomms15041 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Merrikhi, Yaser
Clark, Kelsey
Albarran, Eddy
Parsa, Mohammadbagher
Zirnsak, Marc
Moore, Tirin
Noudoost, Behrad
Spatial working memory alters the efficacy of input to visual cortex
title Spatial working memory alters the efficacy of input to visual cortex
title_full Spatial working memory alters the efficacy of input to visual cortex
title_fullStr Spatial working memory alters the efficacy of input to visual cortex
title_full_unstemmed Spatial working memory alters the efficacy of input to visual cortex
title_short Spatial working memory alters the efficacy of input to visual cortex
title_sort spatial working memory alters the efficacy of input to visual cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414175/
https://www.ncbi.nlm.nih.gov/pubmed/28447609
http://dx.doi.org/10.1038/ncomms15041
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