A novel role of cellular interactions in vascular calcification

A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. Potent and illustrative mechanisms have been proven to exist in both bone metabolism and VC...

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Detalles Bibliográficos
Autores principales: Bardeesi, Adham Sameer A., Gao, Jingwei, Zhang, Kun, Yu, Suntian, Wei, Mengchao, Liu, Pinming, Huang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414234/
https://www.ncbi.nlm.nih.gov/pubmed/28464904
http://dx.doi.org/10.1186/s12967-017-1190-z
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author Bardeesi, Adham Sameer A.
Gao, Jingwei
Zhang, Kun
Yu, Suntian
Wei, Mengchao
Liu, Pinming
Huang, Hui
author_facet Bardeesi, Adham Sameer A.
Gao, Jingwei
Zhang, Kun
Yu, Suntian
Wei, Mengchao
Liu, Pinming
Huang, Hui
author_sort Bardeesi, Adham Sameer A.
collection PubMed
description A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. Potent and illustrative mechanisms have been proven to exist in both bone metabolism and VC, indicating that these two processes share similarities in onset and progression. Multiple osteoblast-like cells and signaling pathways are involved in the process of VC. In this review, we summarized the roles of different osteoblast-like cells and we emphasized on how they communicated and interacted with each other using different signaling pathways. Further studies are needed to uncover the underlying mechanisms and to provide novel therapies for VC.
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spelling pubmed-54142342017-05-03 A novel role of cellular interactions in vascular calcification Bardeesi, Adham Sameer A. Gao, Jingwei Zhang, Kun Yu, Suntian Wei, Mengchao Liu, Pinming Huang, Hui J Transl Med Review A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. Potent and illustrative mechanisms have been proven to exist in both bone metabolism and VC, indicating that these two processes share similarities in onset and progression. Multiple osteoblast-like cells and signaling pathways are involved in the process of VC. In this review, we summarized the roles of different osteoblast-like cells and we emphasized on how they communicated and interacted with each other using different signaling pathways. Further studies are needed to uncover the underlying mechanisms and to provide novel therapies for VC. BioMed Central 2017-05-03 /pmc/articles/PMC5414234/ /pubmed/28464904 http://dx.doi.org/10.1186/s12967-017-1190-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Bardeesi, Adham Sameer A.
Gao, Jingwei
Zhang, Kun
Yu, Suntian
Wei, Mengchao
Liu, Pinming
Huang, Hui
A novel role of cellular interactions in vascular calcification
title A novel role of cellular interactions in vascular calcification
title_full A novel role of cellular interactions in vascular calcification
title_fullStr A novel role of cellular interactions in vascular calcification
title_full_unstemmed A novel role of cellular interactions in vascular calcification
title_short A novel role of cellular interactions in vascular calcification
title_sort novel role of cellular interactions in vascular calcification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414234/
https://www.ncbi.nlm.nih.gov/pubmed/28464904
http://dx.doi.org/10.1186/s12967-017-1190-z
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