Activin A more prominently regulates muscle mass in primates than does GDF8

Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad TGF-β inhibition suggests another family member nega...

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Detalles Bibliográficos
Autores principales: Latres, Esther, Mastaitis, Jason, Fury, Wen, Miloscio, Lawrence, Trejos, Jesus, Pangilinan, Jeffrey, Okamoto, Haruka, Cavino, Katie, Na, Erqian, Papatheodorou, Angelos, Willer, Tobias, Bai, Yu, Hae Kim, Jee, Rafique, Ashique, Jaspers, Stephen, Stitt, Trevor, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414365/
https://www.ncbi.nlm.nih.gov/pubmed/28452368
http://dx.doi.org/10.1038/ncomms15153

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