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Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique

BACKGROUND: Hypoglycaemia is a frequent complication among admitted children, particularly in malaria-endemic areas. This study aimed to estimate the occurrence of hypoglycaemia not only upon admission but throughout the first 72 h of hospitalization in children admitted with malaria. METHODS: A sim...

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Autores principales: Madrid, Lola, Sitoe, Antonio, Varo, Rosauro, Nhampossa, Tacilta, Lanaspa, Miguel, Nhama, Abel, Acácio, Sozinho, Riaño, Isolina, Casellas, Aina, Bassat, Quique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414384/
https://www.ncbi.nlm.nih.gov/pubmed/28464825
http://dx.doi.org/10.1186/s12936-017-1840-x
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author Madrid, Lola
Sitoe, Antonio
Varo, Rosauro
Nhampossa, Tacilta
Lanaspa, Miguel
Nhama, Abel
Acácio, Sozinho
Riaño, Isolina
Casellas, Aina
Bassat, Quique
author_facet Madrid, Lola
Sitoe, Antonio
Varo, Rosauro
Nhampossa, Tacilta
Lanaspa, Miguel
Nhama, Abel
Acácio, Sozinho
Riaño, Isolina
Casellas, Aina
Bassat, Quique
author_sort Madrid, Lola
collection PubMed
description BACKGROUND: Hypoglycaemia is a frequent complication among admitted children, particularly in malaria-endemic areas. This study aimed to estimate the occurrence of hypoglycaemia not only upon admission but throughout the first 72 h of hospitalization in children admitted with malaria. METHODS: A simple pilot study to continuously monitor glycaemia in children aged 0–10 years, admitted with malaria in a rural hospital was conducted in Southern Mozambique by inserting continuous glucose monitors (CGMs) in subcutaneous tissue of the abdominal area, producing glycaemia readings every 5 min. RESULTS: Glucose was continuously monitored during a mean of 48 h, in 74 children. Continuous measurements of blood glucose were available for 72/74 children (97.3%). Sixty-five of them were admitted with density-specific malaria diagnosis criteria (17 severe, 48 uncomplicated). Five children (7.7%) had hypoglycaemia (<54 mg/dL) on admission as detected by routine capillary determination. Analysing the data collected by the CGMs, hypoglycaemia episodes (<54 mg/dL) were detected in 10/65 (15.4%) of the children, of which 7 (10.8%) could be classified as severe (≤45 mg/dL). No risk factors were independently associated with the presence of at least one episode of hypoglycaemia (<54 mg/dL) during hospitalization. Only one death occurred among a normoglycaemic child. All episodes of hypoglycaemia detected by CGMs were subclinical episodes or not perceived by caregivers or clinical staff. CONCLUSIONS: Hypoglycaemia beyond admission in children with malaria appears to be much more frequent than what had been previously described. The clinical relevance of these episodes of hypoglycaemia in the medium or long term remains to be determined.
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spelling pubmed-54143842017-05-04 Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique Madrid, Lola Sitoe, Antonio Varo, Rosauro Nhampossa, Tacilta Lanaspa, Miguel Nhama, Abel Acácio, Sozinho Riaño, Isolina Casellas, Aina Bassat, Quique Malar J Research BACKGROUND: Hypoglycaemia is a frequent complication among admitted children, particularly in malaria-endemic areas. This study aimed to estimate the occurrence of hypoglycaemia not only upon admission but throughout the first 72 h of hospitalization in children admitted with malaria. METHODS: A simple pilot study to continuously monitor glycaemia in children aged 0–10 years, admitted with malaria in a rural hospital was conducted in Southern Mozambique by inserting continuous glucose monitors (CGMs) in subcutaneous tissue of the abdominal area, producing glycaemia readings every 5 min. RESULTS: Glucose was continuously monitored during a mean of 48 h, in 74 children. Continuous measurements of blood glucose were available for 72/74 children (97.3%). Sixty-five of them were admitted with density-specific malaria diagnosis criteria (17 severe, 48 uncomplicated). Five children (7.7%) had hypoglycaemia (<54 mg/dL) on admission as detected by routine capillary determination. Analysing the data collected by the CGMs, hypoglycaemia episodes (<54 mg/dL) were detected in 10/65 (15.4%) of the children, of which 7 (10.8%) could be classified as severe (≤45 mg/dL). No risk factors were independently associated with the presence of at least one episode of hypoglycaemia (<54 mg/dL) during hospitalization. Only one death occurred among a normoglycaemic child. All episodes of hypoglycaemia detected by CGMs were subclinical episodes or not perceived by caregivers or clinical staff. CONCLUSIONS: Hypoglycaemia beyond admission in children with malaria appears to be much more frequent than what had been previously described. The clinical relevance of these episodes of hypoglycaemia in the medium or long term remains to be determined. BioMed Central 2017-05-02 /pmc/articles/PMC5414384/ /pubmed/28464825 http://dx.doi.org/10.1186/s12936-017-1840-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Madrid, Lola
Sitoe, Antonio
Varo, Rosauro
Nhampossa, Tacilta
Lanaspa, Miguel
Nhama, Abel
Acácio, Sozinho
Riaño, Isolina
Casellas, Aina
Bassat, Quique
Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title_full Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title_fullStr Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title_full_unstemmed Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title_short Continuous determination of blood glucose in children admitted with malaria in a rural hospital in Mozambique
title_sort continuous determination of blood glucose in children admitted with malaria in a rural hospital in mozambique
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414384/
https://www.ncbi.nlm.nih.gov/pubmed/28464825
http://dx.doi.org/10.1186/s12936-017-1840-x
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