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A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

The 1,3,4-oxadiazole is an aromatic heterocycle valued for its low-lipophilicity in drug development. Substituents at the 2- and/or 5-positions can modulate the heterocycle's electronic and hydrogen bond-accepting capability, while exploiting its use as a carbonyl bioisostere. A new approach to...

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Detalles Bibliográficos
Autores principales:	Tokumaru, Kazuyuki, Johnston, Jeffrey N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414388/ https://www.ncbi.nlm.nih.gov/pubmed/28507694 http://dx.doi.org/10.1039/c7sc00195a

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