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New leads for fragment-based design of rhenium/technetium radiopharmaceutical agents

Multiple possibilities for the coordination of fac-[Re(CO)(3)(H(2)O)(3)](+) to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro. The large number of rhenium metal complex binding si...

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Detalles Bibliográficos
Autores principales: Brink, Alice, Helliwell, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414402/
https://www.ncbi.nlm.nih.gov/pubmed/28512575
http://dx.doi.org/10.1107/S2052252517003475