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Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients

BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following...

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Autores principales: Głażewska, Edyta Katarzyna, Niczyporuk, Marek, Ławicki, Sławomir, Szmitkowski, Maciej, Donejko, Magdalena, Zajkowska, Monika, Będkowska, Grażyna Ewa, Przylipiak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414720/
https://www.ncbi.nlm.nih.gov/pubmed/28490884
http://dx.doi.org/10.2147/TCRM.S125595
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author Głażewska, Edyta Katarzyna
Niczyporuk, Marek
Ławicki, Sławomir
Szmitkowski, Maciej
Donejko, Magdalena
Zajkowska, Monika
Będkowska, Grażyna Ewa
Przylipiak, Andrzej
author_facet Głażewska, Edyta Katarzyna
Niczyporuk, Marek
Ławicki, Sławomir
Szmitkowski, Maciej
Donejko, Magdalena
Zajkowska, Monika
Będkowska, Grażyna Ewa
Przylipiak, Andrzej
author_sort Głażewska, Edyta Katarzyna
collection PubMed
description BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. METHODS: Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement. RESULTS: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score. CONCLUSION: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker.
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spelling pubmed-54147202017-05-10 Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients Głażewska, Edyta Katarzyna Niczyporuk, Marek Ławicki, Sławomir Szmitkowski, Maciej Donejko, Magdalena Zajkowska, Monika Będkowska, Grażyna Ewa Przylipiak, Andrzej Ther Clin Risk Manag Original Research BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. METHODS: Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement. RESULTS: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score. CONCLUSION: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker. Dove Medical Press 2017-04-27 /pmc/articles/PMC5414720/ /pubmed/28490884 http://dx.doi.org/10.2147/TCRM.S125595 Text en © 2017 Głażewska et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Głażewska, Edyta Katarzyna
Niczyporuk, Marek
Ławicki, Sławomir
Szmitkowski, Maciej
Donejko, Magdalena
Zajkowska, Monika
Będkowska, Grażyna Ewa
Przylipiak, Andrzej
Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title_full Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title_fullStr Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title_full_unstemmed Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title_short Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
title_sort narrowband ultraviolet b light treatment changes plasma concentrations of mmp-3, mmp-9 and timp-3 in psoriatic patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414720/
https://www.ncbi.nlm.nih.gov/pubmed/28490884
http://dx.doi.org/10.2147/TCRM.S125595
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