Cargando…
Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414720/ https://www.ncbi.nlm.nih.gov/pubmed/28490884 http://dx.doi.org/10.2147/TCRM.S125595 |
_version_ | 1783233412639752192 |
---|---|
author | Głażewska, Edyta Katarzyna Niczyporuk, Marek Ławicki, Sławomir Szmitkowski, Maciej Donejko, Magdalena Zajkowska, Monika Będkowska, Grażyna Ewa Przylipiak, Andrzej |
author_facet | Głażewska, Edyta Katarzyna Niczyporuk, Marek Ławicki, Sławomir Szmitkowski, Maciej Donejko, Magdalena Zajkowska, Monika Będkowska, Grażyna Ewa Przylipiak, Andrzej |
author_sort | Głażewska, Edyta Katarzyna |
collection | PubMed |
description | BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. METHODS: Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement. RESULTS: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score. CONCLUSION: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker. |
format | Online Article Text |
id | pubmed-5414720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54147202017-05-10 Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients Głażewska, Edyta Katarzyna Niczyporuk, Marek Ławicki, Sławomir Szmitkowski, Maciej Donejko, Magdalena Zajkowska, Monika Będkowska, Grażyna Ewa Przylipiak, Andrzej Ther Clin Risk Manag Original Research BACKGROUND: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. METHODS: Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement. RESULTS: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score. CONCLUSION: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker. Dove Medical Press 2017-04-27 /pmc/articles/PMC5414720/ /pubmed/28490884 http://dx.doi.org/10.2147/TCRM.S125595 Text en © 2017 Głażewska et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Głażewska, Edyta Katarzyna Niczyporuk, Marek Ławicki, Sławomir Szmitkowski, Maciej Donejko, Magdalena Zajkowska, Monika Będkowska, Grażyna Ewa Przylipiak, Andrzej Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title | Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title_full | Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title_fullStr | Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title_full_unstemmed | Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title_short | Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients |
title_sort | narrowband ultraviolet b light treatment changes plasma concentrations of mmp-3, mmp-9 and timp-3 in psoriatic patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414720/ https://www.ncbi.nlm.nih.gov/pubmed/28490884 http://dx.doi.org/10.2147/TCRM.S125595 |
work_keys_str_mv | AT głazewskaedytakatarzyna narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT niczyporukmarek narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT ławickisławomir narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT szmitkowskimaciej narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT donejkomagdalena narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT zajkowskamonika narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT bedkowskagrazynaewa narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients AT przylipiakandrzej narrowbandultravioletblighttreatmentchangesplasmaconcentrationsofmmp3mmp9andtimp3inpsoriaticpatients |