TIE-2 expressing monocytes in human cancers

Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated mono...

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Detalles Bibliográficos
Autores principales: Turrini, Riccardo, Pabois, Angélique, Xenarios, Ioannis, Coukos, George, Delaloye, Jean-François, Doucey, Marie-Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414874/
https://www.ncbi.nlm.nih.gov/pubmed/28507810
http://dx.doi.org/10.1080/2162402X.2017.1303585
Descripción
Sumario:Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.

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