TIE-2 expressing monocytes in human cancers

Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated mono...

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Autores principales: Turrini, Riccardo, Pabois, Angélique, Xenarios, Ioannis, Coukos, George, Delaloye, Jean-François, Doucey, Marie-Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414874/
https://www.ncbi.nlm.nih.gov/pubmed/28507810
http://dx.doi.org/10.1080/2162402X.2017.1303585
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author Turrini, Riccardo
Pabois, Angélique
Xenarios, Ioannis
Coukos, George
Delaloye, Jean-François
Doucey, Marie-Agnès
author_facet Turrini, Riccardo
Pabois, Angélique
Xenarios, Ioannis
Coukos, George
Delaloye, Jean-François
Doucey, Marie-Agnès
author_sort Turrini, Riccardo
collection PubMed
description Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.
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spelling pubmed-54148742017-05-15 TIE-2 expressing monocytes in human cancers Turrini, Riccardo Pabois, Angélique Xenarios, Ioannis Coukos, George Delaloye, Jean-François Doucey, Marie-Agnès Oncoimmunology Review Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM. Taylor & Francis 2017-03-16 /pmc/articles/PMC5414874/ /pubmed/28507810 http://dx.doi.org/10.1080/2162402X.2017.1303585 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Turrini, Riccardo
Pabois, Angélique
Xenarios, Ioannis
Coukos, George
Delaloye, Jean-François
Doucey, Marie-Agnès
TIE-2 expressing monocytes in human cancers
title TIE-2 expressing monocytes in human cancers
title_full TIE-2 expressing monocytes in human cancers
title_fullStr TIE-2 expressing monocytes in human cancers
title_full_unstemmed TIE-2 expressing monocytes in human cancers
title_short TIE-2 expressing monocytes in human cancers
title_sort tie-2 expressing monocytes in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414874/
https://www.ncbi.nlm.nih.gov/pubmed/28507810
http://dx.doi.org/10.1080/2162402X.2017.1303585
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AT delaloyejeanfrancois tie2expressingmonocytesinhumancancers
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