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Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL

BACKGROUD: Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated....

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Autores principales: Kawaguchi, Yoshiharu, Nakano, Masato, Yasuda, Taketoshi, Seki, Shoji, Suzuki, Kayo, Yahara, Yasuhito, Makino, Hiroto, Kitajima, Isao, Kimura, Tomoatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414934/
https://www.ncbi.nlm.nih.gov/pubmed/28467440
http://dx.doi.org/10.1371/journal.pone.0174881
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author Kawaguchi, Yoshiharu
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Kitajima, Isao
Kimura, Tomoatsu
author_facet Kawaguchi, Yoshiharu
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Kitajima, Isao
Kimura, Tomoatsu
author_sort Kawaguchi, Yoshiharu
collection PubMed
description BACKGROUD: Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study. METHODS AND FINDINGS: This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP. CONCLUSIONS: The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL.
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spelling pubmed-54149342017-05-14 Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL Kawaguchi, Yoshiharu Nakano, Masato Yasuda, Taketoshi Seki, Shoji Suzuki, Kayo Yahara, Yasuhito Makino, Hiroto Kitajima, Isao Kimura, Tomoatsu PLoS One Research Article BACKGROUD: Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study. METHODS AND FINDINGS: This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP. CONCLUSIONS: The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL. Public Library of Science 2017-05-03 /pmc/articles/PMC5414934/ /pubmed/28467440 http://dx.doi.org/10.1371/journal.pone.0174881 Text en © 2017 Kawaguchi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kawaguchi, Yoshiharu
Nakano, Masato
Yasuda, Taketoshi
Seki, Shoji
Suzuki, Kayo
Yahara, Yasuhito
Makino, Hiroto
Kitajima, Isao
Kimura, Tomoatsu
Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title_full Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title_fullStr Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title_full_unstemmed Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title_short Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
title_sort serum biomarkers in patients with ossification of the posterior longitudinal ligament (opll): inflammation in opll
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414934/
https://www.ncbi.nlm.nih.gov/pubmed/28467440
http://dx.doi.org/10.1371/journal.pone.0174881
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