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Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine
Microtubule-targeting agents (MTAs), widely used as biological probes and chemotherapeutic drugs, bind directly to tubulin subunits and “kinetically stabilize” microtubules, suppressing the characteristic self-assembly process of dynamic instability. However, the molecular-level mechanisms of kineti...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415019/ https://www.ncbi.nlm.nih.gov/pubmed/28298489 http://dx.doi.org/10.1091/mbc.E16-08-0567 |