Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protect...

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Autores principales: Rajakrishnan, R., Lekshmi, R., Benil, P.B., Thomas, J., AlFarhan, A.H., Rakesh, V., Khalaf, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415120/
https://www.ncbi.nlm.nih.gov/pubmed/28490944
http://dx.doi.org/10.1016/j.sjbs.2017.01.001
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author Rajakrishnan, R.
Lekshmi, R.
Benil, P.B.
Thomas, J.
AlFarhan, A.H.
Rakesh, V.
Khalaf, S.
author_facet Rajakrishnan, R.
Lekshmi, R.
Benil, P.B.
Thomas, J.
AlFarhan, A.H.
Rakesh, V.
Khalaf, S.
author_sort Rajakrishnan, R.
collection PubMed
description Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities.
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spelling pubmed-54151202017-05-10 Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent Rajakrishnan, R. Lekshmi, R. Benil, P.B. Thomas, J. AlFarhan, A.H. Rakesh, V. Khalaf, S. Saudi J Biol Sci Original Article Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities. Elsevier 2017-05 2017-01-08 /pmc/articles/PMC5415120/ /pubmed/28490944 http://dx.doi.org/10.1016/j.sjbs.2017.01.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rajakrishnan, R.
Lekshmi, R.
Benil, P.B.
Thomas, J.
AlFarhan, A.H.
Rakesh, V.
Khalaf, S.
Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title_full Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title_fullStr Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title_full_unstemmed Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title_short Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
title_sort phytochemical evaluation of roots of plumbago zeylanica l. and assessment of its potential as a nephroprotective agent
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415120/
https://www.ncbi.nlm.nih.gov/pubmed/28490944
http://dx.doi.org/10.1016/j.sjbs.2017.01.001
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