Cargando…
Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often do...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415204/ https://www.ncbi.nlm.nih.gov/pubmed/28422960 http://dx.doi.org/10.1371/journal.pgen.1006739 |