Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

Retroviral vectors have shown their curative potential in clinical trials correcting monogenetic disorders. However, therapeutic benefits were compromised due to vector-induced dysregulation of cellular genes and leukemia development in a subset of patients. Bromodomain and extraterminal domain (BET...

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Detalles Bibliográficos
Autores principales: El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415309/
https://www.ncbi.nlm.nih.gov/pubmed/28624199
http://dx.doi.org/10.1016/j.omtn.2017.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415309/
https://www.ncbi.nlm.nih.gov/pubmed/28624199
http://dx.doi.org/10.1016/j.omtn.2017.04.002

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