Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells

Gene-modified B cells expressing immunoglobulin G (IgG) fusion proteins have been shown to induce tolerance in several autoimmune and other disease models. However, lack of a vector suitable for gene transfer to human B cells has been an obstacle for translation of this approach. To overcome this hu...

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Detalles Bibliográficos
Autores principales: Wang, Xiaomei, Herzog, Roland W., Byrne, Barry J., Kumar, Sandeep R.P., Zhou, Qi, Buchholz, Christian J., Biswas, Moanaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415320/
https://www.ncbi.nlm.nih.gov/pubmed/28480307
http://dx.doi.org/10.1016/j.omtm.2017.03.005

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