Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase

MtATP-phosphoribosyltransferase (MtATP-PRT) is an enzyme catalyzing the first step of the biosynthesis of L-histidine in Mycobacterium tuberculosis, and proposed to be regulated via an allosteric mechanism. Native mass spectrometry (MS) reveals MtATP-PRT to exist as a hexamer. Conformational changes...

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Detalles Bibliográficos
Autores principales: Pacholarz, Kamila J., Burnley, Rebecca J., Jowitt, Thomas A., Ordsmith, Victoria, Pisco, João Pedro, Porrini, Massimiliano, Larrouy-Maumus, Gérald, Garlish, Rachel A., Taylor, Richard J., de Carvalho, Luiz Pedro Sório, Barran, Perdita E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415358/
https://www.ncbi.nlm.nih.gov/pubmed/28392260
http://dx.doi.org/10.1016/j.str.2017.03.005

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