Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders

Human immunodeficiency virus-1 (HIV-1) mainly relies on host factors to complete its life cycle. Hence, it is very important to identify HIV-regulated host proteins. Proteomics is an excellent technique for this purpose because of its high throughput and sensitivity. In this review, we summarized cu...

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Detalles Bibliográficos
Autores principales: Zhang, Lijun, Jia, Xiaofang, Jin, Jun-O, Lu, Hongzhou, Tan, Zhimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415375/
https://www.ncbi.nlm.nih.gov/pubmed/28391008
http://dx.doi.org/10.1016/j.gpb.2016.11.002
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author Zhang, Lijun
Jia, Xiaofang
Jin, Jun-O
Lu, Hongzhou
Tan, Zhimi
author_facet Zhang, Lijun
Jia, Xiaofang
Jin, Jun-O
Lu, Hongzhou
Tan, Zhimi
author_sort Zhang, Lijun
collection PubMed
description Human immunodeficiency virus-1 (HIV-1) mainly relies on host factors to complete its life cycle. Hence, it is very important to identify HIV-regulated host proteins. Proteomics is an excellent technique for this purpose because of its high throughput and sensitivity. In this review, we summarized current technological advances in proteomics, including general isobaric tags for relative and absolute quantitation (iTRAQ) and stable isotope labeling by amino acids in cell culture (SILAC), as well as subcellular proteomics and investigation of posttranslational modifications. Furthermore, we reviewed the applications of proteomics in the discovery of HIV-related diseases and HIV infection mechanisms. Proteins identified by proteomic studies might offer new avenues for the diagnosis and treatment of HIV infection and the related diseases.
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spelling pubmed-54153752017-05-10 Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders Zhang, Lijun Jia, Xiaofang Jin, Jun-O Lu, Hongzhou Tan, Zhimi Genomics Proteomics Bioinformatics Review Human immunodeficiency virus-1 (HIV-1) mainly relies on host factors to complete its life cycle. Hence, it is very important to identify HIV-regulated host proteins. Proteomics is an excellent technique for this purpose because of its high throughput and sensitivity. In this review, we summarized current technological advances in proteomics, including general isobaric tags for relative and absolute quantitation (iTRAQ) and stable isotope labeling by amino acids in cell culture (SILAC), as well as subcellular proteomics and investigation of posttranslational modifications. Furthermore, we reviewed the applications of proteomics in the discovery of HIV-related diseases and HIV infection mechanisms. Proteins identified by proteomic studies might offer new avenues for the diagnosis and treatment of HIV infection and the related diseases. Elsevier 2017-04 2017-04-06 /pmc/articles/PMC5415375/ /pubmed/28391008 http://dx.doi.org/10.1016/j.gpb.2016.11.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Lijun
Jia, Xiaofang
Jin, Jun-O
Lu, Hongzhou
Tan, Zhimi
Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title_full Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title_fullStr Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title_full_unstemmed Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title_short Recent 5-year Findings and Technological Advances in the Proteomic Study of HIV-associated Disorders
title_sort recent 5-year findings and technological advances in the proteomic study of hiv-associated disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415375/
https://www.ncbi.nlm.nih.gov/pubmed/28391008
http://dx.doi.org/10.1016/j.gpb.2016.11.002
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