Animal Models for Tuberculosis in Translational and Precision Medicine

Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for id...

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Detalles Bibliográficos
Autores principales: Zhan, Lingjun, Tang, Jun, Sun, Mengmeng, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415616/
https://www.ncbi.nlm.nih.gov/pubmed/28522990
http://dx.doi.org/10.3389/fmicb.2017.00717
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author Zhan, Lingjun
Tang, Jun
Sun, Mengmeng
Qin, Chuan
author_facet Zhan, Lingjun
Tang, Jun
Sun, Mengmeng
Qin, Chuan
author_sort Zhan, Lingjun
collection PubMed
description Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models.
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spelling pubmed-54156162017-05-18 Animal Models for Tuberculosis in Translational and Precision Medicine Zhan, Lingjun Tang, Jun Sun, Mengmeng Qin, Chuan Front Microbiol Microbiology Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models. Frontiers Media S.A. 2017-05-04 /pmc/articles/PMC5415616/ /pubmed/28522990 http://dx.doi.org/10.3389/fmicb.2017.00717 Text en Copyright © 2017 Zhan, Tang, Sun and Qin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhan, Lingjun
Tang, Jun
Sun, Mengmeng
Qin, Chuan
Animal Models for Tuberculosis in Translational and Precision Medicine
title Animal Models for Tuberculosis in Translational and Precision Medicine
title_full Animal Models for Tuberculosis in Translational and Precision Medicine
title_fullStr Animal Models for Tuberculosis in Translational and Precision Medicine
title_full_unstemmed Animal Models for Tuberculosis in Translational and Precision Medicine
title_short Animal Models for Tuberculosis in Translational and Precision Medicine
title_sort animal models for tuberculosis in translational and precision medicine
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415616/
https://www.ncbi.nlm.nih.gov/pubmed/28522990
http://dx.doi.org/10.3389/fmicb.2017.00717
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AT tangjun animalmodelsfortuberculosisintranslationalandprecisionmedicine
AT sunmengmeng animalmodelsfortuberculosisintranslationalandprecisionmedicine
AT qinchuan animalmodelsfortuberculosisintranslationalandprecisionmedicine

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