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Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease

BACKGROUND: Genome-wide association studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk factor for childhood-onset asthma. OBJECTIVE: We sought to investigate in vivo the functional role of ORMDL3 in disease incep...

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Detalles Bibliográficos
Autores principales:	Löser, Stephan, Gregory, Lisa G., Zhang, Youming, Schaefer, Katrein, Walker, Simone A., Buckley, James, Denney, Laura, Dean, Charlotte H., Cookson, William O.C., Moffatt, Miriam F., Lloyd, Clare M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2017
Materias:	Asthma and Lower Airway Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415707/ https://www.ncbi.nlm.nih.gov/pubmed/27623174 http://dx.doi.org/10.1016/j.jaci.2016.07.033

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