Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

BACKGROUND: Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial damage and fragility, airway remodelling and sub-epithelia...

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Detalles Bibliográficos
Autores principales: Murray, Lynne A., Dunmore, Rebecca, Camelo, Ana, Da Silva, Carla A., Gustavsson, Malin J., Habiel, David M., Hackett, Tillie L, Hogaboam, Cory M., Sleeman, Matthew A., Knight, Darryl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415733/
https://www.ncbi.nlm.nih.gov/pubmed/28468623
http://dx.doi.org/10.1186/s12931-017-0565-2

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