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The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases
Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415870/ https://www.ncbi.nlm.nih.gov/pubmed/28523001 http://dx.doi.org/10.3389/fimmu.2017.00503 |
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author | Scheraga, Rachel G. Southern, Brian D. Grove, Lisa M. Olman, Mitchell A. |
author_facet | Scheraga, Rachel G. Southern, Brian D. Grove, Lisa M. Olman, Mitchell A. |
author_sort | Scheraga, Rachel G. |
collection | PubMed |
description | Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis (CF), and acute lung injury/acute respiratory distress syndrome (ARDS). TRPV4 has been shown to play a role in lung diseases associated with lung parenchymal stretch or stiffness. TRPV4 indirectly mediates hypotonicity-induced smooth muscle contraction and airway remodeling in asthma. Further, the literature suggests that in CF TRPV4 may improve ciliary beat frequency enhancing mucociliary clearance, while at the same time increasing pro-inflammatory cytokine secretion/lung tissue injury. Currently it is understood that the role of TRPV4 in immune cell function and associated lung tissue injury/ARDS may depend on the injury stimulus. Uncovering the downstream mechanisms of TRPV4 action in pulmonary inflammatory diseases is likely important to understanding disease pathogenesis and may lead to novel therapeutics. |
format | Online Article Text |
id | pubmed-5415870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54158702017-05-18 The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases Scheraga, Rachel G. Southern, Brian D. Grove, Lisa M. Olman, Mitchell A. Front Immunol Immunology Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis (CF), and acute lung injury/acute respiratory distress syndrome (ARDS). TRPV4 has been shown to play a role in lung diseases associated with lung parenchymal stretch or stiffness. TRPV4 indirectly mediates hypotonicity-induced smooth muscle contraction and airway remodeling in asthma. Further, the literature suggests that in CF TRPV4 may improve ciliary beat frequency enhancing mucociliary clearance, while at the same time increasing pro-inflammatory cytokine secretion/lung tissue injury. Currently it is understood that the role of TRPV4 in immune cell function and associated lung tissue injury/ARDS may depend on the injury stimulus. Uncovering the downstream mechanisms of TRPV4 action in pulmonary inflammatory diseases is likely important to understanding disease pathogenesis and may lead to novel therapeutics. Frontiers Media S.A. 2017-05-04 /pmc/articles/PMC5415870/ /pubmed/28523001 http://dx.doi.org/10.3389/fimmu.2017.00503 Text en Copyright © 2017 Scheraga, Southern, Grove and Olman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Scheraga, Rachel G. Southern, Brian D. Grove, Lisa M. Olman, Mitchell A. The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title | The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title_full | The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title_fullStr | The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title_full_unstemmed | The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title_short | The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases |
title_sort | role of transient receptor potential vanilloid 4 in pulmonary inflammatory diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415870/ https://www.ncbi.nlm.nih.gov/pubmed/28523001 http://dx.doi.org/10.3389/fimmu.2017.00503 |
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