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Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance

[Image: see text] Monoclonal antibodies labeled with near-infrared (NIR) fluorophores have potential use in disease detection, intraoperative imaging, and pharmacokinetic characterization of therapeutic antibodies in both the preclinical and clinical setting. Recent work has shown conjugation of NIR...

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Detalles Bibliográficos
Autores principales:	Cilliers, Cornelius, Nessler, Ian, Christodolu, Nikolas, Thurber, Greg M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415873/ https://www.ncbi.nlm.nih.gov/pubmed/28294622 http://dx.doi.org/10.1021/acs.molpharmaceut.6b01091

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