DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target

R.SwaI, a Type IIP restriction endonuclease, recognizes a palindromic eight base pair (bp) symmetric sequence, 5΄-ATTTAAAT-3΄, and cleaves that target at its center to generate blunt-ended DNA fragments. Here, we report three crystal structures of SwaI: unbound enzyme, a DNA-bound complex with calci...

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Detalles Bibliográficos
Autores principales: Shen, Betty W., Heiter, Daniel F., Lunnen, Keith D., Wilson, Geoffrey G., Stoddard, Barry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415892/
https://www.ncbi.nlm.nih.gov/pubmed/28180307
http://dx.doi.org/10.1093/nar/gkw1200

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