InFlo: a novel systems biology framework identifies cAMP-CREB1 axis as a key modulator of platinum resistance in ovarian cancer

Characterizing the complex interplay of cellular processes in cancer would enable the discovery of key mechanisms underlying its development and progression. Published approaches to decipher driver mechanisms do not explicitly model tissue-specific changes in pathway networks and the regulatory disr...

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Detalles Bibliográficos
Autores principales: Dimitrova, N, Nagaraj, A B, Razi, A, Singh, S, Kamalakaran, S, Banerjee, N, Joseph, P, Mankovich, A, Mittal, P, DiFeo, A, Varadan, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Oncogenomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415943/
https://www.ncbi.nlm.nih.gov/pubmed/27819677
http://dx.doi.org/10.1038/onc.2016.398

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